Alexithymia-an independent risk factor for impulsive-compulsive disorders in Parkinson's disease.
Identifieur interne : 000671 ( Main/Exploration ); précédent : 000670; suivant : 000672Alexithymia-an independent risk factor for impulsive-compulsive disorders in Parkinson's disease.
Auteurs : Katharina S. Goerlich-Dobre [Allemagne] ; Catharina Probst ; Lina Winter ; Karsten Witt ; Günther Deuschl ; Bettina Möller ; Thilo Van EimerenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Affective Symptoms (diagnosis), Affective Symptoms (etiology), Aged, Compulsive Behavior (diagnosis), Compulsive Behavior (etiology), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (psychology), Psychiatric Status Rating Scales, Questionnaires, Risk Factors, Statistics, Nonparametric.
- MESH :
- complications : Parkinson Disease.
- diagnosis : Affective Symptoms, Compulsive Behavior.
- etiology : Affective Symptoms, Compulsive Behavior.
- psychology : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Questionnaires, Risk Factors, Statistics, Nonparametric.
Abstract
Impulsive-compulsive disorders (ICDs) are frequent side effects of dopaminergic medication in Parkinson's disease (PD). Alexithymia, a personality trait characterized by difficulties identifying and describing feelings and an externally oriented thinking style, has been linked to various impulse-control problems in the general population. In PD, the prevalence of alexithymia is approximately twice as high as in the general population. However, whether alexithymia is associated with ICDs in PD is currently unknown. We examined the relationship between self-reported ICDs and alexithymia in a sample of 91 PD patients (89 on dopaminergic medication). Additional self-report measures assessed impulsivity, depression, anxiety, behavioral inhibition/approach, and emotion-regulation strategies. We observed that alexithymia, and particularly difficulty identifying feelings and difficulty describing feelings, was significantly correlated with ICDs, even when controlling for impulsivity, anxiety, and depression. In addition, a group analysis revealed that PD patients with clinical and moderate levels of alexithymia had significantly more ICDs than non-alexithymic patients, suggesting that even moderately high alexithymia levels increase the risk for ICDs in PD. Our results identify alexithymia as an independent risk factor for ICDs in PD. Thus, the inclusion of alexithymia in the neuropsychiatric assessment of patients with PD may help identify patients at risk for ICDs.
DOI: 10.1002/mds.25679
PubMed: 24123483
Affiliations:
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Goerlich-Dobre</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Medical Center Schleswig-Holstein, Kiel Campus, Kiel, Germany; Department of Neurology, Christian-Albrechts University, Kiel, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Schleswig-Holstein, Kiel Campus, Kiel, Germany; Department of Neurology, Christian-Albrechts University, Kiel, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical School, RWTH Aachen University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Probst, Catharina" sort="Probst, Catharina" uniqKey="Probst C" first="Catharina" last="Probst">Catharina Probst</name></author><author><name sortKey="Winter, Lina" sort="Winter, Lina" uniqKey="Winter L" first="Lina" last="Winter">Lina Winter</name></author><author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Moller, Bettina" sort="Moller, Bettina" uniqKey="Moller B" first="Bettina" last="Möller">Bettina Möller</name></author><author><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24123483</idno><idno type="pmid">24123483</idno><idno type="doi">10.1002/mds.25679</idno><idno type="wicri:Area/PubMed/Corpus">000733</idno><idno type="wicri:Area/PubMed/Curation">000733</idno><idno type="wicri:Area/PubMed/Checkpoint">000688</idno><idno type="wicri:Area/Ncbi/Merge">003D64</idno><idno type="wicri:Area/Ncbi/Curation">003D64</idno><idno type="wicri:Area/Ncbi/Checkpoint">003D64</idno><idno type="wicri:Area/Main/Merge">000671</idno><idno type="wicri:Area/Main/Curation">000671</idno><idno type="wicri:Area/Main/Exploration">000671</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Alexithymia-an independent risk factor for impulsive-compulsive disorders in Parkinson's disease.</title><author><name sortKey="Goerlich Dobre, Katharina S" sort="Goerlich Dobre, Katharina S" uniqKey="Goerlich Dobre K" first="Katharina S" last="Goerlich-Dobre">Katharina S. 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Alexithymia, a personality trait characterized by difficulties identifying and describing feelings and an externally oriented thinking style, has been linked to various impulse-control problems in the general population. In PD, the prevalence of alexithymia is approximately twice as high as in the general population. However, whether alexithymia is associated with ICDs in PD is currently unknown. We examined the relationship between self-reported ICDs and alexithymia in a sample of 91 PD patients (89 on dopaminergic medication). Additional self-report measures assessed impulsivity, depression, anxiety, behavioral inhibition/approach, and emotion-regulation strategies. We observed that alexithymia, and particularly difficulty identifying feelings and difficulty describing feelings, was significantly correlated with ICDs, even when controlling for impulsivity, anxiety, and depression. In addition, a group analysis revealed that PD patients with clinical and moderate levels of alexithymia had significantly more ICDs than non-alexithymic patients, suggesting that even moderately high alexithymia levels increase the risk for ICDs in PD. Our results identify alexithymia as an independent risk factor for ICDs in PD. Thus, the inclusion of alexithymia in the neuropsychiatric assessment of patients with PD may help identify patients at risk for ICDs.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Aix-la-Chapelle</li></settlement></list><tree><noCountry><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><name sortKey="Moller, Bettina" sort="Moller, Bettina" uniqKey="Moller B" first="Bettina" last="Möller">Bettina Möller</name><name sortKey="Probst, Catharina" sort="Probst, Catharina" uniqKey="Probst C" first="Catharina" last="Probst">Catharina Probst</name><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name><name sortKey="Winter, Lina" sort="Winter, Lina" uniqKey="Winter L" first="Lina" last="Winter">Lina Winter</name><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name></noCountry><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Goerlich Dobre, Katharina S" sort="Goerlich Dobre, Katharina S" uniqKey="Goerlich Dobre K" first="Katharina S" last="Goerlich-Dobre">Katharina S. 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